Skip to content

Hampton Inn & Suites St. Louis/South I-55

Hotel Exterior
1 of 12
Trip Advisor average rating of 5 by 1744 reviewsBased on 1,744 Reviews



3:00 PM


11:00 AM

Visit the Gateway to the West

Off I-55, we’re 25 minutes from St. Louis Lambert International Airport, and 10 minutes from Mercy Hospital South and the VA Medical Center. The Gateway Arch, downtown, and Anheuser-Busch Brewery are within 20 minutes. Enjoy our indoor pool, fitness center, free WiFi, and free hot breakfast.

Our Amenities

  • Connecting Rooms

  • Free hot breakfast

  • Free parking

  • Free WiFi

  • Non-smoking rooms

  • Digital Key

  • Indoor pool

  • Fitness center

  • Pet-friendly rooms

  • Business center

  • Meeting rooms

Hotel Policies

Self parking
Valet parking
Not available
Not available
Not available
In/Out privileges
Other parking Information
Parking Lot

Rooms and suites

View All Rooms

Meetings and events

  • Total event space
    726sq. ft.
  • Largest room setup
    726sq. ft.
  • Meeting rooms
  • Guest rooms

Traveling as a group?

Stay together by booking 10 or more rooms instantly online.

Book a Room Block

Planning an Event?

Submit your event details to find out what we can offer.

Request a Proposal

Create an Attendee Website

Build your own attendee website or contact the hotel to create it for you. Everything you need is in your room block booking confirmation email, including your event dates, the 7-letter hotel code, and your group’s unique special rate code.

Where to find us

Skip the map
Hampton by Hilton Pin
Hampton Inn & Suites St. Louis/South I-55
4200 MidAmerica Lane, Saint Louis, Missouri, 63129, USA
Map marker
See What's Nearby